Breast-cancer diagnosis with nipple fluid bFGF

Lancet. 2000 Aug 12;356(9229):567. doi: 10.1016/S0140-6736(00)02587-3.


Early diagnosis of breast cancer is the key to extending survival of breast-cancer patients. We found that the concentrations of nipple fluid bFGF (basic fibroblast growth factor) was significantly increased in breast-cancer patients compared with concentrations in controls (1717 ng/L [SD 706] vs 19 ng/L [19]; Student's t test p=0.027). Measurement of bFGF in nipple fluid could be a useful diagnostic tool for breast cancer, and deserves further study.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biomarkers, Tumor / analysis
  • Body Fluids / chemistry*
  • Breast Neoplasms / diagnosis*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fibroblast Growth Factor 2 / analysis*
  • Humans
  • Nipples / metabolism*


  • Biomarkers, Tumor
  • Fibroblast Growth Factor 2