Applicability of zinc complex of L-carnosine for medical use

Biochemistry (Mosc). 2000 Jul;65(7):817-23.


Zinc complex of L-carnosine (L-CAZ; generic name Polaprezinc) is the first drug for oral administration in which zinc plays an essential role. L-CAZ was approved as an anti-ulcer drug of membrane protection type. Characterization of L-CAZ was achieved by various spectroscopic methods along with elemental analysis. Zinc ion coordinates with L-carnosine to form a quadridentate 1:1 complex of polymeric nature in order to maintain low strain of chelate rings. L-CAZ can remain in stomach juice without rapid dissociation and adhere to ulcerous lesion specifically, after which L-carnosine and zinc are released to heal the ulcer. L-CAZ exhibited high efficacy in clinical use without any serious side effect. L-CAZ exhibited an inhibitory effect on Helicobacter pylori. Physicochemical aspects on carnosine, zinc, and zinc complex can explain favorable features of L-CAZ as a drug.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Ulcer Agents / pharmacology
  • Anti-Ulcer Agents / therapeutic use*
  • Carnosine / analogs & derivatives*
  • Carnosine / pharmacology
  • Carnosine / therapeutic use*
  • Helicobacter pylori / drug effects
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Organometallic Compounds / pharmacology
  • Organometallic Compounds / therapeutic use*
  • Rats
  • Zinc / chemistry*
  • Zinc Compounds


  • Anti-Ulcer Agents
  • Organometallic Compounds
  • Zinc Compounds
  • polaprezinc
  • Carnosine
  • Zinc