[Chronic necrotizing pulmonary aspergillosis and ankylosing spondylarthritis]

Rev Mal Respir. 2000 Jun;17(3):683-6.
[Article in French]


Fibro-bullous disease is a late complication of ankylosing spondylarthritis. Its radiologic features frequently mimics tuberculosis or excavated neoplasm. About 50 to 65% of patients with ankylosing spondylarthritis have chronic aspergillus colonization of their airways. Pulmonary aspergillosis infection occurs in 10 to 30% during evolution. We report two cases of patients with spondylarthritis who developed chronic necrotizing pulmonary aspergillosis. Diagnosis was based on serology, mycologic examination of expectoration and in one case on histology obtain by transbronchial biopsies. Pulmonary complications due to aspergillus species frequently reveal an associated fibro-bullous disease in patients with ankylosing spondylarthritis. This can be reported to diminished chest wall movements in such patients. Treatment is based on administration of anti-fungal drugs. In case of medical treatment failure, thoracic surgery may be indicated.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use
  • Aspergillosis / diagnosis
  • Aspergillosis / drug therapy
  • Aspergillosis / etiology*
  • Biopsy
  • Bronchoscopy
  • Chronic Disease
  • Diagnosis, Differential
  • Fever / microbiology
  • Humans
  • Lung Diseases, Fungal / diagnosis
  • Lung Diseases, Fungal / drug therapy
  • Lung Diseases, Fungal / etiology*
  • Male
  • Middle Aged
  • Necrosis
  • Spondylitis, Ankylosing / complications*
  • Tomography, X-Ray Computed


  • Antifungal Agents