Effectiveness and complications of vascular access closure devices after interventional procedures

J Invasive Cardiol. 2000 Aug;12(8):395-9.


Background: Vascular closure devices are designed to obtain a fast hemostasis of the vascular access site after diagnostic and interventional procedures. This result should be obtained with a low incidence of complications.

Methods: A retrospective, non-randomized study was performed to evaluate the success rate and vascular complications associated with the use of two different vascular sealing devices [Angio-Seal (Daig Corporation, Minnetonka, Minnesota) and Prostar (Perclose, Inc., Redwood City, California)] after interventional procedures.

Results: Eight-hundred and twenty-seven devices were used (245 Angio-Seal and 582 Prostar). Angio-Seal success rate was 92% with a 2.5% rate of vascular complications; Prostar success rate was 89% with a 3.4% rate of vascular complications. Multivariate logistic regression analysis identified advanced age (p < 0.05) and lower weight (p < 0.05) as independent predictors of vascular complications associated with Angio-Seal use, while diabetes (p < 0.05) was found to be a predictor of vascular complications in the Prostar group. Abciximab use and larger sheath size were not associated with an increased probability of vascular complications.

Conclusion: Angio-Seal and Prostar obtain a fast vascular access hemostasis after interventional procedures, with a low incidence of major vascular complications.

Publication types

  • Comparative Study

MeSH terms

  • Angioplasty, Balloon, Coronary / adverse effects
  • Atherectomy, Coronary / adverse effects
  • Catheters, Indwelling / adverse effects*
  • Equipment Design
  • Female
  • Femoral Artery
  • Hemostasis, Surgical / instrumentation*
  • Humans
  • Male
  • Middle Aged
  • Postoperative Hemorrhage / etiology
  • Postoperative Hemorrhage / surgery*
  • Punctures / adverse effects*
  • Retrospective Studies