The molecular genetics of human herpesvirus 8

Hosp Med. 2000 May;61(5):306-9. doi: 10.12968/hosp.2000.61.5.1327.

Abstract

Epidemiological evidence from the early 1990s suggested that a sexually transmitted infectious agent other than the HIV virus was associated with the development of Kaposi's sarcoma in patients with HIV. A novel gamma herpesvirus was identified in Kaposi's sarcoma lesions. The molecular genetics of this virus are reviewed in this article.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / virology*
  • CASP8 and FADD-Like Apoptosis Regulating Protein
  • Carrier Proteins / genetics
  • Cyclin D
  • Cyclins / genetics
  • Genes, bcl-2 / genetics
  • Herpesvirus 8, Human / genetics*
  • Humans
  • Interleukin-6 / genetics
  • Intracellular Signaling Peptides and Proteins*
  • Macrophage Inflammatory Proteins / genetics
  • Receptors, Cell Surface / genetics
  • Sarcoma, Kaposi / virology*
  • Skin Neoplasms / virology*

Substances

  • CASP8 and FADD-Like Apoptosis Regulating Protein
  • CFLAR protein, human
  • Carrier Proteins
  • Cyclin D
  • Cyclins
  • Interleukin-6
  • Intracellular Signaling Peptides and Proteins
  • Macrophage Inflammatory Proteins
  • Receptors, Cell Surface