Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease

Int J Colorectal Dis. 2000 Jun;15(3):144-60. doi: 10.1007/s003840000227.


Inflammatory bowel diseases (IBDs) in humans are complex chronic inflammatory disorders of largely unknown cause. Several mouse models that in some respects resemble human IBDs have recently been developed and have provided new insights into immunoregulatory processes in the gut. Both genetic and environmental factors have been shown to be involved in chronic intestinal inflammation. In most of the models CD4+ T lymphocytes have been identified as central mediators of inflammation. Inappropriate activation of T(H)1-dominated cytokine pathways upon contact with luminal bacterial antigens and lack of tolerance appear to be crucial for intestinal pathology. We present a brief overview of important animal models of IBD and describe the recent progress in understanding the mechanisms that contribute to chronic intestinal inflammation. Furthermore, novel immunotherapeutic approaches derived from such animal models are discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • CD4 Antigens
  • Cytokines / pharmacology*
  • Disease Models, Animal*
  • Humans
  • Immunotherapy*
  • Inflammation
  • Inflammatory Bowel Diseases / immunology*
  • Inflammatory Bowel Diseases / therapy
  • Mice
  • Mice, Transgenic
  • Saguinus
  • T-Lymphocytes / immunology


  • CD4 Antigens
  • Cytokines