Detection and quantification of CD4(+) T cells with specificity for a new major histocompatibility complex class II-restricted influenza A virus matrix protein epitope in peripheral blood of influenza patients

J Virol. 2000 Sep;74(18):8740-3. doi: 10.1128/jvi.74.18.8740-8743.2000.

Abstract

FVFTLTVPS was identified as the core sequence of a new major histocompatibility complex class II-restricted T-cell epitope of influenza virus matrix protein. Epitope-specific CD4(+) T cells were detected in the peripheral blood of patients with frequencies of up to 0.94%, depending on the number of additional terminal amino acids.

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / analysis
  • CD4-Positive T-Lymphocytes / immunology*
  • Epitopes, T-Lymphocyte
  • Genes, MHC Class II / immunology*
  • HLA-DR4 Antigen / analysis
  • HLA-DR4 Antigen / immunology
  • Haplotypes
  • Humans
  • Influenza A virus / immunology*
  • Influenza, Human / blood
  • Influenza, Human / immunology*
  • Influenza, Human / virology
  • Viral Matrix Proteins / blood
  • Viral Matrix Proteins / immunology*

Substances

  • Amino Acids
  • Epitopes, T-Lymphocyte
  • HLA-DR4 Antigen
  • M-protein, influenza virus
  • Viral Matrix Proteins