Abstract
FVFTLTVPS was identified as the core sequence of a new major histocompatibility complex class II-restricted T-cell epitope of influenza virus matrix protein. Epitope-specific CD4(+) T cells were detected in the peripheral blood of patients with frequencies of up to 0.94%, depending on the number of additional terminal amino acids.
MeSH terms
-
Amino Acid Sequence
-
Amino Acids / analysis
-
CD4-Positive T-Lymphocytes / immunology*
-
Epitopes, T-Lymphocyte
-
Genes, MHC Class II / immunology*
-
HLA-DR4 Antigen / analysis
-
HLA-DR4 Antigen / immunology
-
Haplotypes
-
Humans
-
Influenza A virus / immunology*
-
Influenza, Human / blood
-
Influenza, Human / immunology*
-
Influenza, Human / virology
-
Viral Matrix Proteins / blood
-
Viral Matrix Proteins / immunology*
Substances
-
Amino Acids
-
Epitopes, T-Lymphocyte
-
HLA-DR4 Antigen
-
M-protein, influenza virus
-
Viral Matrix Proteins