Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit

Nucleic Acids Res. 2000 Sep 1;28(17):3185-96. doi: 10.1093/nar/28.17.3185.


The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Codon / genetics*
  • Conserved Sequence / genetics*
  • Evolution, Molecular*
  • Feedback
  • Frameshifting, Ribosomal / genetics*
  • Humans
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Phylogeny
  • Polyamines / metabolism*
  • RNA, Catalytic / chemistry
  • RNA, Catalytic / genetics*
  • RNA, Catalytic / metabolism
  • RNA, Messenger / chemistry
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Regulatory Sequences, Nucleic Acid / genetics
  • Sequence Alignment


  • Codon
  • Polyamines
  • RNA, Catalytic
  • RNA, Messenger