[Genetic aspects of arterial hypertension: the role of Y chromosome and mitochondrial DNA]

Ross Fiziol Zh Im I M Sechenova. 2000 Jun;86(6):671-80.
[Article in Russian]


A study on hybrids from reciprocal crossing of the SHR-SP and the WKY has shown that Y-chromosome and mitochondrial DNA the affect development of the spontaneous hypertension. The Y-chromosome takes part in disorders of baroreceptive sensitivity in phenylnephrine assay associated with hypertension. Although our findings suggest that structural remodelling of peripheral vascular resistance and an increase in noradrenaline-dependent vasocostriction is genetically determined in hypertensive rats, we could not corroborate the role of the Y-chromosome and mitochondrial DNA in the process. A difference was shown between male and female SHR-SP in the level of arterial pressure and in development of the vascular structure changes.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Baroreflex
  • DNA, Mitochondrial*
  • Female
  • Hindlimb / blood supply
  • Hypertension / genetics*
  • Hypertension / physiopathology
  • In Vitro Techniques
  • Male
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Vascular Resistance
  • Y Chromosome*


  • DNA, Mitochondrial