Obstructive airway disease caused by Moraxella catarrhalis after renal transplantation

Pediatr Nephrol. 2000 Aug;14(8-9):707-9. doi: 10.1007/pl00013421.


We report a case of severe acute obstructive airway disease 2 months after renal transplantation in a 16-year-old patient with Biedl-Bardet syndrome who was transplanted for end-stage renal failure secondary to cystic kidney disease. Symptoms of severe obstructive airway disease developed 2 months after transplantation under immunosuppression with prednisone, azathioprine, and tacrolimus. The patient did not develop signs of infection; progressive shortness of breath remained the only symptom for several weeks. After extensive diagnostic evaluation, bronchoalveolar lavage revealed Moraxella catarrhalis as the single infectious agent. After 3 weeks of appropriate antibiotic therapy, symptoms of obstructive airway disease were completely relieved. This atypical presentation of Moraxella infection in an immunocompromised host represents a rare complication of renal transplantation, especially in young patients. Special aspects such as frequency, diagnosis, differential diagnosis, and management of this rare complication of renal transplantation in a pediatric patient are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Airway Obstruction / diagnostic imaging
  • Airway Obstruction / etiology*
  • Ampicillin / therapeutic use
  • Bronchoalveolar Lavage Fluid / cytology
  • Drug Therapy, Combination / therapeutic use
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Diseases, Cystic / complications
  • Kidney Diseases, Cystic / surgery
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation*
  • Lung / diagnostic imaging
  • Male
  • Moraxella catarrhalis*
  • Neisseriaceae Infections / diagnosis*
  • Neisseriaceae Infections / drug therapy
  • Postoperative Complications*
  • Sulbactam / therapeutic use
  • Syndrome
  • Tomography, X-Ray Computed


  • Immunosuppressive Agents
  • Ampicillin
  • Sulbactam