Identification of a chemical tool for the orphan nuclear receptor FXR

J Med Chem. 2000 Aug 10;43(16):2971-4. doi: 10.1021/jm0002127.
No abstract available

MeSH terms

  • Animals
  • Biological Availability
  • Cell Line
  • Cell-Free System
  • Combinatorial Chemistry Techniques
  • DNA-Binding Proteins / agonists*
  • Humans
  • Isoxazoles / chemical synthesis*
  • Isoxazoles / chemistry
  • Isoxazoles / pharmacokinetics
  • Isoxazoles / pharmacology
  • Mice
  • Rats
  • Rats, Inbred F344
  • Receptors, Cytoplasmic and Nuclear / agonists*
  • Transcription Factors / agonists*
  • Transfection
  • Triglycerides / blood

Substances

  • DNA-Binding Proteins
  • Isoxazoles
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • Triglycerides
  • farnesoid X-activated receptor
  • GW 4064