Synthesis of Ecteinascidin ET-743 and Phthalascidin Pt-650 From Cyanosafracin B

Org Lett. 2000 Aug 10;2(16):2545-8. doi: 10.1021/ol0062502.

Abstract

An efficient new process is described for the synthesis of ecteinascidin ET-743 (1) and phthalascidin (2), starting from readily available cyanosafracin B (3).

MeSH terms

  • Antineoplastic Agents, Alkylating / chemical synthesis*
  • Antineoplastic Agents, Alkylating / chemistry
  • Azocines*
  • Dioxoles / chemical synthesis*
  • Dioxoles / chemistry
  • Indicators and Reagents
  • Isoquinolines / chemical synthesis*
  • Isoquinolines / chemistry
  • Models, Molecular
  • Molecular Conformation
  • Phthalimides / chemical synthesis*
  • Phthalimides / chemistry
  • Quinones*
  • Tetrahydroisoquinolines
  • Trabectedin

Substances

  • Antineoplastic Agents, Alkylating
  • Azocines
  • Dioxoles
  • Indicators and Reagents
  • Isoquinolines
  • Phthalimides
  • Quinones
  • Tetrahydroisoquinolines
  • cyanosafracin B
  • phthalascidin
  • Trabectedin