Different expression of some molecular markers in sporadic cancer of the left and right colon

Eur J Cancer Prev. 2000 Aug;9(4):265-8. doi: 10.1097/00008469-200008000-00006.


The expression of cytoplasmic c-erbB2, epidermal growth factor receptor (EGFR), proliferating cell nuclear antigen (PCNA) and dipeptidylpeptidase IV (DPP IV) was significantly higher in sporadic cancer of the right than of the left colon. In addition, cytoplasmic c-erbB2 displayed the same difference in the adjacent (less than 2 cm) and distant (more than 5 cm from the tumour margin) mucosa. The findings cannot be related to Dukes staging. It is suggested that different ontogenic development of the right (from the midgut) and the left (from the hindgut) colon may be a possible explanation. Therefore, data on the expression of different molecular markers in colorectal cancer and surrounding mucosa should always be supplemented by data on tumour location.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor / analysis*
  • Colonic Neoplasms / diagnosis
  • Colonic Neoplasms / metabolism*
  • Cytoplasm / metabolism
  • Dipeptidyl Peptidase 4 / metabolism
  • ErbB Receptors / metabolism
  • Female
  • Humans
  • Intestinal Mucosa / metabolism
  • Male
  • Middle Aged
  • Proliferating Cell Nuclear Antigen / metabolism
  • Receptor, ErbB-2 / metabolism


  • Biomarkers, Tumor
  • Proliferating Cell Nuclear Antigen
  • ErbB Receptors
  • Receptor, ErbB-2
  • Dipeptidyl Peptidase 4