Comparison of macular versus paramacular retinal sensitivity to femtosecond laser pulses

J Biomed Opt. 2000 Jul;5(3):315-20. doi: 10.1117/1.430002.

Abstract

Single 130 fs laser pulses in the near-IR (800 nm) were used to create ophthalmoscopically viewed minimum visible lesions (MVLs) within the macular and paramacular regions in rhesus monkey eyes. MVL thresholds at 1 and 24 h are reported as the 50% probability for damage (ED50) together with their fiducial limits at the 95% confidence level. These measured thresholds are compared with previously reported thresholds for near-IR and visible wavelengths for both macular and paramacular areas. Threshold doses were lower at the 24 h reading than at the 1 h reading for both retinal regions and the ED50s for the macula were slightly lower than for the paramacula. We measured the 24 h MVL ED50 thresholds to be 0.35 and 0.55 microJ for the macular and paramacular areas, respectively. The combined data for both areas yielded a threshold of 0.45 microJ.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Eye Injuries / etiology
  • Eye Injuries / prevention & control
  • Lasers* / adverse effects
  • Macaca mulatta
  • Macula Lutea / physiology*
  • Ophthalmoscopy / methods
  • Reproducibility of Results
  • Retina / injuries
  • Sensory Thresholds / physiology