The biology of aging

Mayo Clin Proc. 2000 Jan:75 Suppl:S3-8; discussion S8-9.


Nothing has been demonstrated to slow or reverse the primary aging process in humans; instead, the factors that are known to affect longevity do so by their influence on disease development, which is part of secondary aging. Preventive strategies against secondary aging are aimed at maintaining health and functional capacity and rectangularizing, rather than extending, the survival curve. Interventions for preventive geriatrics and successful aging include a low-fat, low-energy diet with a high content of fruits and vegetables; exercise; and hormone replacement.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging / drug effects
  • Aging / pathology
  • Aging / physiology*
  • Animals
  • Dehydroepiandrosterone / therapeutic use
  • Diet, Fat-Restricted
  • Energy Intake
  • Exercise / physiology
  • Female
  • Geriatrics / methods
  • Hormone Replacement Therapy
  • Humans
  • Longevity / physiology
  • Male
  • Muscle, Skeletal / physiology
  • Obesity / complications
  • Oxygen Consumption
  • Primary Prevention / methods
  • Sex Characteristics


  • Dehydroepiandrosterone