Testosterone and muscle protein metabolism

Mayo Clin Proc. 2000 Jan;75 Suppl:S55-9; discussion S59-60.

Abstract

This presentation discusses recent investigations into testosterone's effects on muscle protein metabolism. Protein synthesis is the principal end point, but protein breakdown and the availability of an amino acid pool are important to the process of net muscle protein synthesis. The effects of other hormones--including growth hormone, oxoandrolone (a synthetically derived testosterone), and androstenedione--on muscle protein synthesis also are discussed. Effects in both normal and elderly men are considered.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging / drug effects
  • Aging / physiology
  • Amino Acids / drug effects
  • Amino Acids / physiology
  • Anabolic Agents / metabolism
  • Anabolic Agents / therapeutic use
  • Androstenedione / metabolism
  • Androstenedione / therapeutic use
  • Growth Hormone / physiology
  • Humans
  • Male
  • Middle Aged
  • Models, Biological
  • Muscle Proteins / drug effects
  • Muscle Proteins / metabolism*
  • Muscular Atrophy / drug therapy
  • Muscular Atrophy / etiology
  • Oxandrolone / metabolism
  • Oxandrolone / therapeutic use
  • Testosterone / physiology*
  • Time Factors

Substances

  • Amino Acids
  • Anabolic Agents
  • Muscle Proteins
  • Testosterone
  • Androstenedione
  • Oxandrolone
  • Growth Hormone