Diesel exhaust as a model xenobiotic in allergic inflammation

Immunopharmacology. 2000 Jul 25;48(3):325-7. doi: 10.1016/s0162-3109(00)00234-4.


We investigated the effects of diesel exhaust particulates on the human allergic response using in vivo human nasal challenges. Diesel particles and phenanthrene, one of their constituent polyaromatic hydrocarbons, were shown to enhance total allergic antibody (IgE) production, enhance allergen-specific IgE in the presence of allergen, and induce sensitization to a neoantigen.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Hypersensitivity / immunology*
  • Immunoglobulin E / immunology*
  • Vehicle Emissions* / adverse effects
  • Xenobiotics / adverse effects


  • Vehicle Emissions
  • Xenobiotics
  • Immunoglobulin E