Correlation of telomere lengths in normal and cancers tissue in the large bowel

Cancer Lett. 2000 Oct 1;158(2):179-84. doi: 10.1016/s0304-3835(00)00521-8.


The hypothesis that telomeres in colorectal cancer cells exhibit age-related shortening, as in normal cells of the colorectal epithelium, was tested with samples of non-cancerous mucosa and cancer tissue from 124 patients (aged 29-97 years). Shortening with aging could be demonstrated for both normal and cancer tissues; regression analysis showed rates for length reduction of 44 and 50 base pair/year, respectively. Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blotting, Southern
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology
  • DNA / genetics
  • DNA, Neoplasm / genetics
  • Female
  • Humans
  • Infant
  • Intestinal Mucosa / metabolism
  • Intestine, Large / metabolism*
  • Male
  • Middle Aged
  • Regression Analysis
  • Telomere / genetics*


  • DNA, Neoplasm
  • DNA