Fibroblast growth factor signaling is required for the proliferation and patterning of progenitor cells in the developing anterior pituitary

Mech Dev. 2000 Sep;96(2):175-82. doi: 10.1016/s0925-4773(00)00393-2.

Abstract

The proliferation and patterning of progenitor cells in the anterior pituitary require signals derived from the neuroepithelium of the juxtaposed infundibulum. The infundibulum expresses Fibroblast growth factor (Fgf) 8 and Fgf 18, and FGFs can mimic some of the activities of the infundibulum. The requirement for FGF signaling during growth and patterning of the anterior pituitary has not, however, been established. By blocking FGF receptor signaling in explants of the anterior pituitary cultured in vitro we provide evidence that FGF signaling derived from the infundibulum is required for the proliferation and patterning of progenitor cells in the anterior pituitary.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Patterning
  • Cell Differentiation
  • Cell Division
  • Culture Techniques
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Fibroblast Growth Factor 8
  • Fibroblast Growth Factors / genetics
  • Fibroblast Growth Factors / physiology*
  • Gene Expression Regulation, Developmental
  • In Situ Hybridization
  • Mice
  • Mice, Inbred CBA
  • Pituitary Gland, Anterior / cytology*
  • Pituitary Gland, Anterior / embryology*
  • Pituitary Gland, Anterior / metabolism
  • Pituitary Gland, Posterior / metabolism
  • Pituitary Hormones, Anterior / biosynthesis
  • Signal Transduction
  • Stem Cells / cytology*
  • Stem Cells / metabolism
  • Transcription Factor Pit-1
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • Fgf8 protein, mouse
  • Pit1 protein, mouse
  • Pituitary Hormones, Anterior
  • Transcription Factor Pit-1
  • Transcription Factors
  • fibroblast growth factor 18
  • Fibroblast Growth Factor 8
  • Fibroblast Growth Factors