Abstract
The homeodomain transcription factor Nkx2-1 (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Chick Embryo
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Gene Expression Regulation, Developmental
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Homeodomain Proteins / genetics*
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In Situ Hybridization
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Lung / embryology
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Mice
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Molecular Sequence Data
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Nuclear Proteins / genetics*
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Prosencephalon / embryology
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Sequence Homology, Amino Acid
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Thyroid Gland / embryology
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Thyroid Nuclear Factor 1
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Transcription Factors / genetics*
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Xenopus / embryology*
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Xenopus / genetics*
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Xenopus Proteins*
Substances
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Homeodomain Proteins
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Nkx2-1 protein, mouse
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Nkx2-4 protein, Xenopus
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Nkx2-4 protein, mouse
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Nuclear Proteins
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Thyroid Nuclear Factor 1
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Transcription Factors
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Xenopus Proteins
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nkx2-1 protein, Xenopus