Evaluation of role of concentration and molecular weight of oat beta-glucan in determining effect of viscosity on plasma glucose and insulin following an oral glucose load

Br J Nutr. 2000 Jul;84(1):19-23.


Data from clinical studies established that there was an inverse linear relationship between measures of postprandial blood glucose and insulin responses to an oral glucose load, consumed in a drink, and the logarithm of viscosity of the drink. These data have been re-analysed using concentration and molecular weight as the dependent variables. Molecular weight (M) of the beta-glucans used was determined using high-performance size exclusion chromatography equipped with a triple detector system of right angle light scattering, viscometry and refractive index. A significant relationship between changes in peak blood glucose and a combination of logarithm of the concentration and logarithm of M was found.

MeSH terms

  • Administration, Oral
  • Algorithms
  • Blood Glucose / metabolism*
  • Glucans / chemistry*
  • Glucose / administration & dosage
  • Glucose / pharmacokinetics*
  • Humans
  • Insulin / blood
  • Molecular Weight
  • Viscosity
  • beta-Glucans*


  • Blood Glucose
  • Glucans
  • Insulin
  • beta-Glucans
  • beta-glucan, (1-3)(1-4)-
  • Glucose