Apoptosis: implications for inflammatory bowel disease

Inflamm Bowel Dis. 2000 Aug;6(3):191-205. doi: 10.1097/00054725-200008000-00006.


Cells of the intestinal mucosa live in a harsh environment and therefore rely heavily on the highly regulated process of cell death, apoptosis, to maintain tissue integrity. Imbalance in the intracellular events that modulate apoptosis may contribute to the pathogenesis of inflammatory bowel disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Apoptosis*
  • Caspases / metabolism
  • Cell Division
  • Humans
  • Immunity, Cellular
  • Inflammatory Bowel Diseases / pathology*
  • Intestinal Mucosa / cytology*
  • Intestinal Mucosa / enzymology
  • Lymphocytes / cytology
  • Lymphocytes / immunology
  • Proto-Oncogene Proteins c-bcl-2 / pharmacology


  • Proto-Oncogene Proteins c-bcl-2
  • Caspases