N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship

Acta Biochim Pol. 2000;47(1):95-101.


Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrüggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.

MeSH terms

  • Amino Acids / chemistry*
  • Antiviral Agents / chemistry*
  • Azacitidine / analogs & derivatives*
  • Azacitidine / chemistry*
  • Cell Line
  • Humans
  • Microbial Sensitivity Tests
  • Structure-Activity Relationship


  • Amino Acids
  • Antiviral Agents
  • Azacitidine
  • 6-azacytidine