The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function

J Auton Pharmacol. 1999 Dec;19(6):327-33. doi: 10.1111/j.1365-2680.1999.tb00005.x.


1. This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na+/Cl(-)-dependent noradrenaline transporter (hNAT) and its gene. 2. Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.

Publication types

  • Review

MeSH terms

  • Adrenergic Uptake Inhibitors / pharmacology
  • Animals
  • Biogenic Monoamines / metabolism*
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Desipramine / pharmacology
  • Humans
  • Mutation, Missense / genetics
  • Neurotransmitter Agents / metabolism*
  • Norepinephrine Plasma Membrane Transport Proteins
  • Polymorphism, Genetic / genetics
  • Symporters*


  • Adrenergic Uptake Inhibitors
  • Biogenic Monoamines
  • Carrier Proteins
  • Neurotransmitter Agents
  • Norepinephrine Plasma Membrane Transport Proteins
  • SLC6A2 protein, human
  • Symporters
  • Desipramine