Abstract
Recent progress identifies targeted chromatin remodelling by co-repressor complexes as being an integral component of transcriptional silencing. Here we discuss how chromatin structure and the basal transcriptional machinery are manipulated by the co-repressor complex containing the Mi-2 nucleosomal ATPase, the histone-binding protein RbAp48 and histone deacetylase and by the co-repressor complex containing SIN3, RbAp48 and histone deacetylase. Remarkably, both of these complexes also contain methyl-CpG-binding proteins. This observation provides a molecular mechanism to integrate DNA methylation fully into gene control in vertebrates.
MeSH terms
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Adenosine Triphosphatases / metabolism
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Animals
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Carrier Proteins / metabolism
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Chromatin / chemistry*
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Chromatin / metabolism*
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Chromosomal Proteins, Non-Histone*
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Chromosomes / metabolism
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CpG Islands / genetics
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DNA Methylation
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Gene Silencing
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Histone Deacetylases / metabolism
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Histones / metabolism
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Humans
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Models, Biological
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Nuclear Proteins / metabolism
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Nucleosomes / metabolism
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Receptors, Steroid / metabolism*
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Repressor Proteins*
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Retinoblastoma-Binding Protein 4
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Saccharomyces cerevisiae Proteins*
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Transcription Factors / metabolism
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Transcription, Genetic
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Transcriptional Activation
Substances
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Carrier Proteins
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Chromatin
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Chromosomal Proteins, Non-Histone
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Histones
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Nuclear Proteins
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Nucleosomes
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RBBP4 protein, human
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Receptors, Steroid
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Repressor Proteins
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Retinoblastoma-Binding Protein 4
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SIN3 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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Histone Deacetylases
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Adenosine Triphosphatases