Gangliosides induce cell apoptosis in the cytotoxic line CTLL-2, but not in the promyelocyte leukemia cell line HL-60

Membr Cell Biol. 2000;13(6):811-22.


Gangliosides induce apoptosis in the cells of the IL-2-dependent cytotoxic mouse line CTLL-2. Upon incubation with gangliosides for 24 h, their effect resulting in appearance of apoptotic cells, falls in a series GM2 > GM3 > GM1 > GD1a > GD1b > GT1b. In the presence of rIL-2, apoptosis induced by GM1 is suppressed, whereas that induced by GM2 is enhanced (the effect of intracellular agent C2-Cer is independent of this cytokine). The GM1-induced apoptosis is cancelled by the caspase I inhibitor. The gangliosides under study are not able to induce apoptosis in the promyelocyte leukemia cell line HL-60. Physiological aspects of the phenomenon found are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis* / drug effects
  • Caspase Inhibitors
  • Cell Line
  • Flow Cytometry
  • Gangliosides / classification
  • Gangliosides / physiology*
  • HL-60 Cells
  • Humans
  • Interleukin-2 / pharmacology
  • Mice
  • Oligopeptides / pharmacology
  • Signal Transduction
  • T-Lymphocytes, Cytotoxic / drug effects
  • T-Lymphocytes, Cytotoxic / physiology*


  • Caspase Inhibitors
  • Gangliosides
  • Interleukin-2
  • Oligopeptides
  • L 709049