An expedient route to the Calabar bean alkaloids (-)-physovenine and (-)-physostigmine

A S ElAzab; T Taniguchi; K Ogasawara

doi:10.1021/ol006065o

An expedient route to the Calabar bean alkaloids (-)-physovenine and (-)-physostigmine

Org Lett. 2000 Sep 7;2(18):2757-9. doi: 10.1021/ol006065o.

Authors

A S ElAzab¹, T Taniguchi, K Ogasawara

Affiliation

¹ Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan.

PMID: 10964358
DOI: 10.1021/ol006065o

Abstract

An expedient route to the Calabar bean alkaloids (-)-physovenine and (-)-physostigmine has been devised using a chiral building block which was originally designed for diastereocontrolled construction of aldohexoses.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cholinesterase Inhibitors / chemical synthesis*
Fabaceae / chemistry
Physostigmine / analogs & derivatives*
Physostigmine / chemical synthesis*
Plants, Medicinal
Stereoisomerism

Substances

Cholinesterase Inhibitors
physovenine
Physostigmine