Regioselective synthesis of 1,3,5-triaryl-4-alkylpyrazoles: novel ligands for the estrogen receptor

Org Lett. 2000 Sep 7;2(18):2833-6. doi: 10.1021/ol0062650.


[reaction: see structure] A regioselective synthesis of 4-alkyl-1,3,5-triarylpyrazoles has been developed for the preparation of unsymmetrically substituted systems of interest as ligands for the estrogen receptor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Isomerism
  • Ligands
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / metabolism
  • Receptors, Estrogen / metabolism
  • Selective Estrogen Receptor Modulators / chemical synthesis*
  • Selective Estrogen Receptor Modulators / metabolism


  • Ligands
  • Pyrazoles
  • Receptors, Estrogen
  • Selective Estrogen Receptor Modulators