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. 2000 Sep 7;2(18):2841-3.
doi: 10.1021/ol000173t.

On the Antioxidant Mechanism of Curcumin: Classical Methods Are Needed to Determine Antioxidant Mechanism and Activity

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On the Antioxidant Mechanism of Curcumin: Classical Methods Are Needed to Determine Antioxidant Mechanism and Activity

L R Barclay et al. Org Lett. .

Abstract

[reaction: see structure] The antioxidant activity of curcumin (1, 7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) was determined by inhibition of controlled initiation of styrene oxidation. Synthetic nonphenolic curcuminoids exhibited no antioxidant activity; therefore, curcumin is a classical phenolic chain-breaking antioxidant, donating H atoms from the phenolic groups not the CH(2) group as has been suggested (Jovanovic et al. J. Am. Chem. Soc. 1999, 121, 9677). The antioxidant activities of o-methoxyphenols are decreased in hydrogen bond accepting media.

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