Endogenous and ectopic gland induction by FGF-10

Dev Biol. 2000 Sep 1;225(1):188-200. doi: 10.1006/dbio.2000.9812.


FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Embryonic Induction
  • Embryonic and Fetal Development
  • Fibroblast Growth Factor 10
  • Fibroblast Growth Factors / physiology*
  • Gene Expression Regulation, Developmental / physiology
  • Harderian Gland / embryology*
  • Harderian Gland / physiology
  • Mice
  • Mice, Transgenic


  • Fgf10 protein, mouse
  • Fibroblast Growth Factor 10
  • Fibroblast Growth Factors