Correlation between static automated and scanning laser entoptic perimetry in normal subjects and glaucoma patients

Ophthalmology. 2000 Sep;107(9):1693-701. doi: 10.1016/s0161-6420(00)00248-7.


Objective: To compare the effectiveness of scanning laser entoptic perimetry with static automated perimetry as a noninvasive instrument for screening for glaucomatous damage in visually asymptomatic subjects within the central 60 degrees (diameter) of vision.

Design: A masked cross-sectional study comparing entoptic perimetry to achromatic threshold perimetry.

Participants: Twenty-three subjects and controls from the Sharp Rees-Stealy Hospital and the Shiley Eye Center at the University of California, San Diego.

Testing: Virtual reality-based entoptic perimetry was compared with achromatic threshold perimetry.

Main outcome measures: For each testing session, we compared the presence of a disturbance in the entoptic perimetry stimulus with the presence of defects in visual function as measured by Humphrey automated visual field perimetry.

Results: Scanning laser entoptic perimetry reasonably estimates the overall visual field loss for moderate-to-severe scotomas as measured by the pattern deviation in standard visual field perimetry. Scanning laser entoptic perimetry has a sensitivity from 27% to 90% and a specificity from 50% to 100% for screening moderate-to-severe visual field defects caused by glaucoma within the central 60 degrees diameter of vision.

Conclusions: Scanning laser entoptic perimetry may be an effective and inexpensive screening test in hospitals and community clinics for diagnosing visual field loss caused by glaucoma.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cross-Sectional Studies
  • Double-Blind Method
  • False Positive Reactions
  • Glaucoma / complications
  • Glaucoma / diagnosis*
  • Humans
  • Predictive Value of Tests
  • Reproducibility of Results
  • Retinal Ganglion Cells / pathology*
  • Sensitivity and Specificity
  • Vision Disorders / diagnosis*
  • Vision Disorders / etiology
  • Visual Field Tests / methods*
  • Visual Fields*