Depression in schizophrenia: perspective in the era of "Atypical" antipsychotic agents

Am J Psychiatry. 2000 Sep;157(9):1379-89. doi: 10.1176/appi.ajp.157.9.1379.


Objective: The author sought to provide a contemporary understanding of depression in schizophrenia and promote a treatment orientation.

Method: Computer and library-based resources were used to review the literature on depression in schizophrenia.

Results: Despite multiple definitions of "depression," a substantial rate of depression has consistently been found in patients with schizophrenia. A differential diagnosis can be used to advance the understanding and treatment of depression in schizophrenia, and changes in response to the advent of atypical antipsychotic agents can be understood in the context of this differential diagnosis paradigm.

Conclusions: Depression is an important co-occurring syndrome in schizophrenia. In at least some schizophrenic patients, the stress-vulnerability model has potential as an integrating concept concerning the relationship between depression and psychosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use*
  • Clinical Trials as Topic
  • Comorbidity
  • Depressive Disorder / diagnosis
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / epidemiology*
  • Diagnosis, Differential
  • Disease Susceptibility / epidemiology
  • Hospitalization
  • Humans
  • Models, Psychological
  • Parkinson Disease, Secondary / chemically induced
  • Parkinson Disease, Secondary / diagnosis
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / drug therapy
  • Psychotic Disorders / epidemiology
  • Schizophrenia / diagnosis
  • Schizophrenia / drug therapy
  • Schizophrenia / epidemiology*
  • Schizophrenic Psychology


  • Antipsychotic Agents