Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study

Arzneimittelforschung. 2000 Jul;50(7):659-63. doi: 10.1055/s-0031-1300268.


In a randomized, double-blind, placebo-controlled study the effect of topical dexpanthenol (CAS 81-13-0) formulated in two different lipophilic vehicles on epidermal barrier function in vivo was carried out. Seven days' treatment with dexpanthenol improved stratum corneum hydration and reduced transepidermal water loss. Active treatment was statistically different from the vehicle control on both measures. Our results suggest that topical dexpanthenol formulated in either lipophilic vehicle stabilizes the skin barrier function.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Blood-Air Barrier / drug effects*
  • Chemistry, Pharmaceutical
  • Double-Blind Method
  • Electric Conductivity
  • Epidermis / drug effects*
  • Epidermis / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pantothenic Acid / administration & dosage
  • Pantothenic Acid / analogs & derivatives*
  • Pantothenic Acid / pharmacology
  • Water Loss, Insensible / drug effects*


  • Pantothenic Acid
  • dexpanthenol