Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer

Semin Cancer Biol. 2000 Aug;10(4):255-69. doi: 10.1006/scbi.2000.0326.


Retinoblastoma has contributed much to the understanding of cancer. The protein product of the RB gene, pRB, is a multifaceted regulator of transcription which controls the cell cycle, differentiation and apoptosis in normal development of specific tissues. Elucidating the mechanisms in which pRB plays a critical role will enable novel therapies and strategies for prevention, not only for retinoblastoma, but for cancer in general.

Publication types

  • Review

MeSH terms

  • Genes, Retinoblastoma / genetics*
  • Humans
  • Retinal Neoplasms / genetics*
  • Retinoblastoma / genetics*
  • Retinoblastoma Protein / genetics*


  • Retinoblastoma Protein