Hereditary intestinal cancer

Semin Cancer Biol. 2000 Aug;10(4):289-98. doi: 10.1006/scbi.2000.0148.


Mechanisms involved in hereditary intestinal cancer are likely to play a role in sporadic tumorigenesis as well. Studies focusing on the molecular biology underlying these syndromes has contributed considerably to our knowledge on molecular bases of malignant transformation. It can be concluded, that there are two aspects to the importance of studies on intestinal cancer predisposition. First, the families suffering from cancer proneness need help which can, to some extent, be provided through molecular genetic studies. Second, the resources appointed to such research have produced scientific advances with outstanding importance to our understanding of common malignant diseases.

Publication types

  • Review

MeSH terms

  • Adenomatous Polyposis Coli / complications
  • Adenomatous Polyposis Coli / genetics
  • Adult
  • Age Factors
  • Colorectal Neoplasms / etiology
  • Colorectal Neoplasms / prevention & control
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • Colorectal Neoplasms, Hereditary Nonpolyposis / pathology
  • Gastrointestinal Neoplasms / genetics*
  • Hamartoma Syndrome, Multiple / complications
  • Hamartoma Syndrome, Multiple / diagnosis
  • Humans
  • Infant
  • Middle Aged
  • Peutz-Jeghers Syndrome / complications
  • Peutz-Jeghers Syndrome / diagnosis
  • Risk Factors