Dietary restriction and walking reduce fat deposition in the midthigh in obese older women

Am J Clin Nutr. 2000 Sep;72(3):708-13. doi: 10.1093/ajcn/72.3.708.


Background: It is suggested that fat deposition within midthigh muscle, represented by low-density lean tissue, increases with deconditioning and obesity and is associated with risk factors for cardiovascular disease (CVD) in women.

Objective: We determined the effects of a 6-mo weight loss and walking (3 times/wk) program (WL+AEX) on midthigh low-density lean tissue and glucose and lipid metabolism in 24 sedentary, obese [body mass index (kg/m(2)): 32 +/- 1 (mean +/- SEM)] postmenopausal women aged 58 +/- 1 y.

Design: Total body fat and fat-free mass were measured by using dual-energy X-ray absorptiometry. Intraabdominal fat (IAF), subcutaneous abdominal fat (SAF), midthigh fat, midthigh muscle, and midthigh low-density lean tissue areas were measured by using computed tomography. Glucose and insulin responses were determined with a 3-h oral-glucose-tolerance test.

Results: Body weight decreased 8% (P: < 0.001) and maximal aerobic capacity increased 8% (P: < 0.001) with the weight loss and walking program. Total body fat decreased by 15% (P: < 0.001) whereas fat-free mass did not change. IAF and SAF decreased by 18% and 16%, respectively (P: < 0. 001). Midthigh fat and midthigh low-density lean tissue decreased by 16% and 18%, respectively (P: < 0.001), and midthigh muscle area increased by 7% (P: < 0.05). Fasting plasma insulin decreased by 12% and total glucose and insulin areas under the curve decreased by 6% and 24%, respectively (P: < 0.05). HDL-cholesterol concentrations increased 8% (P: < 0.05) and triacylglycerol concentrations decreased 19% (P: < 0.001).

Conclusion: Increased physical fitness and weight loss reduce midthigh low-density lean tissue and improve glucose and lipid metabolic risk factors for CVD in obese postmenopausal women.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adipose Tissue / pathology*
  • Aged
  • Aging / physiology*
  • Body Composition
  • Diet, Reducing*
  • Female
  • Glucose / metabolism
  • Humans
  • Lipid Metabolism
  • Middle Aged
  • Obesity / metabolism
  • Obesity / pathology*
  • Thigh*
  • Walking*


  • Glucose