Antibacterial Effect of Silver-Zeolite on Oral Bacteria Under Anaerobic Conditions

Dent Mater. 2000 Nov;16(6):452-5. doi: 10.1016/s0109-5641(00)00050-6.

Abstract

Objectives: The purpose of this study was to evaluate the antibacterial effect of silver-zeolite (SZ) against oral bacteria under anaerobic conditions.

Methods: The antibacterial activity of SZ was evaluated by determining the minimum inhibitory concentrations (MICs) using two-fold serial dilutions of SZ in Brain Heart Infusion broth. Release of Ag+ into the broth was measured by an atomic absorption technique.

Results: SZ inhibited the growth of the bacteria tested under anaerobic conditions. The MIC of SZ ranged between 256 and 2048 micrograms/ml, which corresponded to a range of 4.8-38.4 micrograms/ml of Ag+. All strains grew in broth containing 16,384 micrograms/ml of type-A zeolite.

Significance: These results suggested that SZ may be a useful vehicle to provide antibacterial activity to dental materials used even under anaerobic conditions such as deep in the periodontal pocket.

MeSH terms

  • Anaerobiosis
  • Anti-Infective Agents, Local / pharmacology*
  • Bacteria, Anaerobic / drug effects*
  • Microbial Sensitivity Tests
  • Mouth / microbiology
  • Silver Compounds / chemistry
  • Silver Compounds / pharmacology*
  • Spectrophotometry, Atomic
  • Zeolites / pharmacology*

Substances

  • Anti-Infective Agents, Local
  • Silver Compounds
  • Zeolites