Combined large cell neuroendocrine, small cell and squamous carcinomas of the lung with rhabdoid cells

Pathology. 2000 Aug;32(3):209-12.


Two unusual cases of combined lung carcinoma are presented. Both patients, aged 50 and 53 years, had strong histories of cigarette smoking and presented with lung masses. Microscopic examination revealed an uncommon combination of primary lung cancers. Both cases had a dominant histological picture of large cell neuroendocrine carcinoma. The first case was combined with both squamous and small cell carcinomas in almost equal proportions, while the second consisted of large cell neuroendocrine and squamous carcinomas with a focal area of small cell carcinoma. In addition, both cases contained rhabdoid cells. One of the cases pursued an aggressive clinical course with death in 6 months. The other patient presented with recurrent tumor 12 months after the operation and died shortly thereafter. These cases illustrate two examples of uncommon combined lung cancers: large cell neuroendocrine carcinoma combined with squamous carcinoma and small cell carcinoma. An additional feature was the presence of rhabdoid cells in both cases. It is felt that the rhabdoid component is a reflection of de-differentiation or poor differentiation, and may contribute to the aggressive nature of both tumors.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • Carcinoid Tumor / chemistry
  • Carcinoid Tumor / pathology*
  • Carcinoma, Non-Small-Cell Lung / chemistry
  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Carcinoma, Small Cell / chemistry
  • Carcinoma, Small Cell / pathology*
  • Carcinoma, Squamous Cell / chemistry
  • Carcinoma, Squamous Cell / pathology*
  • Fatal Outcome
  • Female
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / pathology*
  • Male
  • Middle Aged
  • Neoplasm Proteins / analysis
  • Neoplasm Recurrence, Local
  • Neoplasms, Multiple Primary
  • Rhabdoid Tumor / chemistry
  • Rhabdoid Tumor / pathology*


  • Biomarkers, Tumor
  • Neoplasm Proteins