The aim of this study was to investigate the effects of the millimeter-wave bioresonance therapy on acute inflammation and stressful conditions in experimental models. Licking reaction in mice as a component of the hypersensitive state evoked by subcutaneous formalin (0.03 ml of 1% solution) injection into the right hind paw was monitored. Different parameters of electro-magnetic stimulation (frequencies 43 GHz and 61 GHz, intensities from 0.1 to 7 mW/cm2, the exposure time for 3 min. or 10 min.) applied to ipsilateral acupoint St.36 were studied. It was found that the millimeter-wave bioresonance therapy improved the condition of experimental animals, accompanying by diminution of licking reaction which was registered for every 10 min. during 2 hours after the formalin test start. Effect of 10 min. irradiation was more demonstrative than 3 min. (frequency 61 GHz, intensity 0.1 mW/cm2). Stimulation with frequency of 61 GHz suppressed licking reaction more deeply than 43 GHz under equal intensities. Most beneficial effects have been observed when minimal (0.1 mW/cm2) intensity of electromagnetic stimulation was used.