Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa

Phytomedicine. 2000 Jul;7(4):303-8. doi: 10.1016/S0944-7113(00)80048-3.

Abstract

Curcumin I, curcumin II (monodemethoxycurcumin) and curcumin III (bisdemethoxycurcumin) from Curcuma longa were assayed for their cytotoxicity, antioxidant and anti-inflammatory activities. These compounds showed activity against leukemia, colon, CNS, melanoma, renal, and breast cancer cell lines. The inhibition of liposome peroxidation by curcumins I-III at 100 microg/ml were 58, 40 and 22%, respectively. The inhibition of COX-I and COX-II enzymes by the curcumins was observed. Curcumins I-III were active against COX-I enzyme at 125 microg/ml and showed 32, 38.5 and 39.2% inhibition of the enzyme, respectively. Curcumins I-III also showed good inhibition of the COX-II enzyme at 125 mg/ml with 89.7, 82.5 and 58.9% inhibition of the enzyme, respectively.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antioxidants / pharmacology*
  • Coumaric Acids / pharmacology
  • Curcumin / analogs & derivatives
  • Curcumin / pharmacology*
  • Cyclooxygenase Inhibitors / pharmacology*
  • Diarylheptanoids
  • Humans
  • Tumor Cells, Cultured / drug effects
  • Zingiberales*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Coumaric Acids
  • Cyclooxygenase Inhibitors
  • Diarylheptanoids
  • bis(4-hydroxycinnamoyl)methane
  • Curcumin
  • demethoxycurcumin