Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins

Curr Opin Neurol. 2000 Aug;13(4):377-84. doi: 10.1097/00019052-200008000-00003.


Alzheimer's disease is the most common neurodegenerative disorder of aging, accounting for an estimated two-thirds of all cases of senile dementia. Epidemiologic studies have failed to resolve any single cause of Alzheimer's disease and suggest a complex etiology, with environmental and genetic factors influencing the pathogenesis. Although the majority of cases are sporadic, a small number display familial clustering. Genetic analyses of these pedigrees have identified four genes that are involved in the development of Alzheimer's disease.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / genetics*
  • Amyloid beta-Peptides / genetics*
  • Apolipoproteins E / genetics
  • Genetic Linkage
  • Humans
  • Membrane Proteins / genetics*
  • Molecular Biology
  • Presenilin-1
  • Presenilin-2


  • Amyloid beta-Peptides
  • Apolipoproteins E
  • Membrane Proteins
  • PSEN1 protein, human
  • PSEN2 protein, human
  • Presenilin-1
  • Presenilin-2