Radiochemical separation of no-carrier-added 177Lu as produced via the 176Yb(n,gamma)177Yb-->177Lu process

Appl Radiat Isot. 2000 Sep;53(3):421-5. doi: 10.1016/s0969-8043(99)00284-5.


The 176Yb(n,gamma)177Yb-beta(-)-->177Lu process was investigated to provide no-carrier-added (nca) 177Lu. The radiochemical separation of the 177Lu from the macro-amounts of the ytterbium target based on the cementation process, i.e. the selective extraction of Yb by Na(Hg) amalgam from Cl-/CH3COO- electrolytes, followed by a final cation exchange purification. The cementation separation process provides a decontamination factor of Yb(III) of 10(4), the cation exchange purification adding a decontamination factor of > 10(2). The nca 177Lu is available in radiochemically pure form despite the chemical similarity of the lanthanides with 75 +/- 5% overall separation yield within 4-5 h. It can be used to synthesise nca 177Lu labelled radiotherapeuticals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, Ion Exchange / methods
  • Indicators and Reagents
  • Isotopes
  • Lutetium / chemistry*
  • Lutetium / isolation & purification
  • Radioisotopes / chemistry*
  • Radioisotopes / isolation & purification
  • Ytterbium / chemistry*


  • Indicators and Reagents
  • Isotopes
  • Radioisotopes
  • Lutetium
  • Ytterbium