The treatment of cluster headaches with prednisone

Dis Nerv Syst. 1975 Jul;36(7):375-6.


Nineteen patients obstinate with cluster headaches whose pain was not mitigated by standard treatment (Methysergide, caffeine, ergotamine preparation, phenobarbital and analgesics) underwent a double blind control study with single crossover for the evaluation of prednisone therapy. Compared to placebo, a single oral dose of prednisone in 17 cases produced sustained improvement. Maintenance administration of prednisone was also effective in decreasing the frequency of attacks; however a single dose of the steroid when headaches began was effective.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Clinical Trials as Topic
  • Drug Evaluation
  • Female
  • Headache / drug therapy*
  • Headache / prevention & control
  • Humans
  • Male
  • Middle Aged
  • Prednisone / therapeutic use*


  • Prednisone