Chloroquine and the Fungal Phagosome

Curr Opin Microbiol. 2000 Aug;3(4):349-53. doi: 10.1016/s1369-5274(00)00102-8.

Abstract

The antimalarial drug chloroquine accumulates inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans. Clearly, clinical studies are required to document the potential therapeutic efficacy of chloroquine or related congeners as adjuvant therapy in fungal disease. Moreover, the diversity of pathogenic microorganisms inhibited and/or killed by chloroquine makes this drug an attractive candidate for prophylactic therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Antifungal Agents / pharmacology*
  • Chloroquine / pharmacology*
  • Cryptococcosis / drug therapy
  • Cryptococcosis / microbiology
  • Cryptococcus neoformans / drug effects*
  • Histoplasma / drug effects*
  • Histoplasmosis / drug therapy
  • Histoplasmosis / microbiology
  • Humans
  • Hydrogen-Ion Concentration
  • Iron / metabolism
  • Mice
  • Phagosomes / drug effects*
  • Phagosomes / microbiology

Substances

  • Antifungal Agents
  • Chloroquine
  • Iron