Melanin and Virulence in Cryptococcus Neoformans

Curr Opin Microbiol. 2000 Aug;3(4):354-8. doi: 10.1016/s1369-5274(00)00103-x.

Abstract

Melanin synthesis has been associated with virulence for the human pathogenic fungus Cryptococcus neoformans. Recent evidence indicates that C. neoformans cells synthesize melanin during infection and that this pigment protects the fungus against immune defense mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cryptococcosis / immunology
  • Cryptococcosis / microbiology*
  • Cryptococcus neoformans / metabolism
  • Cryptococcus neoformans / pathogenicity*
  • Humans
  • Melanins / metabolism*
  • Mice
  • Virulence

Substances

  • Melanins