Docking domains and substrate-specificity determination for MAP kinases

Trends Biochem Sci. 2000 Sep;25(9):448-53. doi: 10.1016/s0968-0004(00)01627-3.


Signalling specificity in eukaryotic cells is maintained by several mechanisms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Evolution, Molecular
  • MAP Kinase Signaling System*
  • Molecular Sequence Data
  • Protein Binding
  • Protein Isoforms
  • Protein Structure, Tertiary
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Substrate Specificity
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism


  • Protein Isoforms
  • Transcription Factors