Conserved noncoding sequences are reliable guides to regulatory elements

Trends Genet. 2000 Sep;16(9):369-72. doi: 10.1016/s0168-9525(00)02081-3.


A 'working draft' of the human genome sequence is now available. Comparisons with the sequences of mouse and other species will be a powerful approach to identifying functional segments of the noncoding regions, such as gene regulatory elements. However, the choice of a species for most effective comparison differs among various loci.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Humans
  • Interleukins / genetics
  • Mice
  • Regulatory Sequences, Nucleic Acid*
  • Species Specificity


  • Interleukins