The pachytene checkpoint

Trends Genet. 2000 Sep;16(9):395-403. doi: 10.1016/s0168-9525(00)02080-1.

Abstract

The pachytene checkpoint prevents meiotic nuclear division in cells that fail to complete meiotic recombination and chromosome synapsis. This control mechanism prevents chromosome missegregation that would lead to the production of aneuploid gametes. The pachytene checkpoint requires a subset of proteins that function in the mitotic DNA damage checkpoint. In budding yeast, the pachytene checkpoint also requires meiosis-specific chromosomal proteins and, unexpectedly, proteins concentrated in the nucleolus. Progress has been made in identifying components of the cell-cycle machinery that are impacted by the checkpoint.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Cycle / physiology*
  • Chromatin / genetics
  • Chromosomes*
  • DNA Damage
  • Meiosis / physiology*
  • Mutation
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics

Substances

  • Chromatin