CCK receptor polymorphisms: an illustration of emerging themes in pharmacogenomics

Trends Pharmacol Sci. 2000 Sep;21(9):346-53. doi: 10.1016/s0165-6147(00)01526-1.


Polymorphisms in G-protein-coupled receptors can alter drug affinity and/or activity. In addition, genetic differences in amino acid sequences can induce ligand-independent signaling, which in turn can lead to disease. With growing efforts in the field of pharmacogenomics, it is anticipated that polymorphism-induced alterations in drug and/or receptor function will be a focus of increasing concern during the course of future drug-development efforts. In this review, the spectrum of pharmacological consequences that result from polymorphisms in the cholecystokinin CCK2 receptor will be discussed, thereby illustrating emerging themes in pharmacogenomics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / metabolism
  • Humans
  • Molecular Sequence Data
  • Polymorphism, Genetic / genetics
  • Polymorphism, Genetic / physiology*
  • Receptors, Cholecystokinin / genetics
  • Receptors, Cholecystokinin / physiology*
  • Species Specificity


  • Receptors, Cholecystokinin
  • GTP-Binding Proteins