Bone mineral density, vitamin D and anticonvulsant therapy

Arq Neuropsiquiatr. 2000 Sep;58(3A):616-20. doi: 10.1590/s0004-282x2000000400003.


The aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy.

Methods: Sixty-nine men, outpatients on chronic anticonvulsant therapy, who had been treated for at least 5 years, were studied, comparing them to thirty healthy controls. Bone mineral density was measured as well as serum levels of calcium, ionized calcium, alkaline phosphatase, PTH, 25-hydroxycholecalciferol and 1, 25-dihydroxycholecalciferol.

Results: No differences in bone mineral density, serum levels of vitamin D and intact-PTH were observed between patients and controls. Bone mineral density was not associated with chronic anticonvulsant therapy.

Conclusion: Those adult patients who were on chronic anticonvulsant therapy and who lived in low latitude regions had normal bone mineral density as well as vitamin D serum levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anticonvulsants / therapeutic use*
  • Bone Density*
  • Case-Control Studies
  • Epilepsy / blood
  • Epilepsy / drug therapy*
  • Epilepsy / physiopathology
  • Humans
  • Male
  • Phenobarbital / therapeutic use
  • Phenytoin / therapeutic use
  • Retrospective Studies
  • Statistics, Nonparametric
  • Vitamin D / blood*


  • Anticonvulsants
  • Vitamin D
  • Phenytoin
  • Phenobarbital